Therapeutic Classification: antidiabetics
Pharmacologic Classification: dipeptidyl peptidase-4 dpp-4 inhibitors
Absorption: Well absorbed following oral administration.
Distribution: Unknown.
Half-Life: Saxagliptin: 2.5 hr; 5-hydroxysaxagliptin: 3.1 hr.
(DPP-4 inhibition)
ROUTE | ONSET | PEAK | DURATION |
---|---|---|---|
PO | unknown | 2 hr (4 hr for 5-hydroxysaxagliptin)‡ | 24 hr |
‡Blood levels.
Contraindicated in:
Use Cautiously in:
CV: HF, peripheral edema (↑ with thiazolidinediones)
Derm: bullous pemphigoid
Endo: hypoglycemia (↑ with sulfonylureas)
GI: abdominal pain, PANCREATITIS, vomiting
Hemat: ↓lymphocyte count
MS: arthralgia, RHABDOMYOLYSIS
Neuro: headache
Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS AND ANGIOEDEMA)
Drug-drug:
Renal Impairment
Lab Test Considerations: