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Pronunciation

tess-TOSS-te-rone sip-EYE-oh-nate

Classifications

Therapeutic Classification: hormones

Pharmacologic Classification: androgens

Indications

BEERS REMS


Action

  • Responsible for the normal growth and development of male sex organs.
  • Maintenance of male secondary sex characteristics:
    • Growth and maturation of the prostate, seminal vesicles, penis, scrotum;
    • Development of male hair distribution;
    • Vocal cord thickening;
    • Alterations in body musculature and fat distribution.
Therapeutic effects:
  • Correction of hormone deficiency in male hypogonadism.

Pharmacokinetics

Absorption: Well absorbed from IM sites; absorbed slowly.

Distribution: Unknown.

Protein Binding: 98%.

Metabolism/Excretion: Metabolized by the liver; 90% eliminated in urine as metabolites.

Half-Life: 8 days.

Time/Action Profile

(androgenic effects)
ROUTEONSETPEAKDURATION
IMunknownunknown2–4 wk



Response is highly variable among individuals; may take mo.



Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: edema, DEEP VEIN THROMBOSIS, MI

Derm: male pattern baldness

EENT: deepening of voice

GI: cholestatic jaundice, drug-induced hepatitis, liver enzymes, nausea, vomiting

GU: change in libido, erectile dysfunction, priapism, prostatic enlargement

Endo: gynecomastia, hirsutism, oligospermia

F and E: hypercalcemia, hyperkalemia, hyperphosphatemia

Local: pain at injection site

Metab: hypercholesterolemia

Neuro: STROKE

Resp: PULMONARY EMBOLISM

Interactions

Drug-drug:

Route/Dosage

Availability

(Generic available)

Assessment

Lab Test Considerations:

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

Depo-Testosterone

Contr. Subst. Schedule

Schedule III (C-III)