section name header

Pronunciation

ka-pe-SITE-a-been

Classifications

Therapeutic Classification: antineoplastics

Pharmacologic Classification: antimetabolites

Indications

High Alert

Action

Therapeutic Effects:

Pharmacokinetics

Absorption: Well absorbed after oral administration.

Distribution: Unknown.

Metabolism/Excretion: Metabolized mostly in tissue and by the liver to 5-fluorouracil; 5-fluorouracil is metabolized by dihydropyrimidine dehydrogenase to a less toxic compound; inactive metabolites are excreted primarily in urine.

Half-life: 45 min.

Time/Action Profile

(plasma concentrations)

ROUTEONSETPEAKDURATION
POunknown1.5 hr (2 hr for 5-fluorouracil)unknown

†Onset of antineoplastic effect is 6 wk.

†Peak 5-fluorouracil concentrations occur at 2 hr.

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: edema, arrhythmias, chest pain, HF, MYOCARDIAL ISCHEMIA/INFARCTION, SUDDEN CARDIAC DEATH.

Derm: dermatitis, hand-and-foot syndrome, nail disorder, alopecia, erythema, rash, STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS.

EENT: eye irritation, epistaxis, rhinorrhea.

F and E: dehydration.

GI: abdominal pain, anorexia, constipation, diarrhea, hyperbilirubinemia, liver enzymes, nausea, stomatitis, vomiting, dyspepsia, NECROTIZING ENTEROCOLITIS, xerostomia.

GU: acute renal failure, fertility.

Hemat: anemia, neutropenia, thrombocytopenia.

MS: arthralgia, myalgia.

Neuro: dysgeusia, fatigue, headache, dizziness, insomnia, peripheral neuropathy.

Resp: cough, dyspnea.
Misc: fever.

Interactions

Drug-Drug:

Drug-Food:

Route/Dosage

see Calculator

Colorectal Cancer

Adjuvant Treatment of Colon Cancer

Renal Impairment

Renal Impairment

Renal Impairment

Advanced or Metastatic Breast Cancer

Renal Impairment

Gastric, Esophageal, or Gastroesophageal Junction Cancer

Unresectable or Metastatic Gastric, Esophageal, or Gastroesophageal Junction Cancer

Renal Impairment

Renal Impairment

Pancreatic Cancer

Renal Impairment

Availability

(Generic available)

Assessment

Lab Test Considerations:

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

Xeloda