High Alert
Absorption: Well absorbed following oral administration.
Distribution: Extensively distributed to tissues.
Protein Binding: ≥92%.
Half-Life: 114 hr.
Contraindicated in:
Use Cautiously in:
CV: ARTERIAL THROMBOSIS, CARDIOVASCULAR DEATH, DEEP VEIN THROMBOSIS, MI
F and E: hyponatremia
GI: constipation, diarrhea, ↑amylase, ↑lipase, ↑liver enzymes, nausea, vomiting, HEPATOTOXICITY
GU: ↑serum creatinine, dysuria
Hemat: anemia, neutropenia, thrombocytopenia
MS: muscle spasm, pain
Neuro: fatigue, dizziness, ENCEPHALOPATHY, headache, STROKE
Resp: PULMONARY EMBOLISM
Misc: SECONDARY MALIGNANCY
Drug-drug:
Renal Impairment
Lab Test Considerations: