Absorption: Well absorbed following oral administration.
Distribution: Well distributed to tissues.
Protein Binding: >99%. Active metabolites are also highly (>99%) bound.
Half-Life: Pioglitazone: 37 hr; total pioglitazone (pioglitazone plus metabolites): 1624 hr.
Contraindicated in:
Use Cautiously in:
CV: edema, HF
EENT: macular edema
GI: ↑liver enzymes, LIVER FAILURE
GU: BLADDER CANCER
Hemat: anemia
MS: fractures (arm, hand, foot) (females), RHABDOMYOLYSIS
Drug-drug:
Drug-Natural Products:
Lab Test Considerations: