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Pronunciation

me-kloe-FEN-am-ate

Classifications

Therapeutic Classification: antirheumatics, nonopioid analgesics

Pharmacologic Classification: nonsteroidal anti inflammatory drugs nsaids

Indications

REMS


Action

  • Inhibits prostaglandin synthesis.
Therapeutic effects:
  • Suppression of pain and inflammation.

Pharmacokinetics

Absorption: Well absorbed from the GI tract.

Distribution: Unknown.

Protein Binding: >99%.

Metabolism/Excretion: Metabolized by the liver; some active metabolites.

Half-Life: 40 min–2 hr.

Time/Action Profile

ROUTEONSETPEAKDURATION
PO (analgesic)within 1 hrunknown4–6 hr
PO (anti-inflammatory)days2–3 wkdays





Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Interactions

Drug-drug:

Drug-Natural Products:

Route/Dosage

Availability

(Generic available)

Assessment

Lab Test Considerations:

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

Meclomen