section name header

Pronunciation

AS-pir-in

Classifications

Therapeutic Classification: antiplatelet agents, antipyretics, nonopioid analgesics

Pharmacologic Classification: salicylates

Indications

BEERS REMS

Unlabeled Uses:

Action

Therapeutic Effects:

Pharmacokinetics

Absorption: Well absorbed from the upper small intestine; absorption from enteric-coated preparations may be unreliable; rectal absorption is slow and variable.

Distribution: Rapidly and widely distributed; crosses the placenta and enters breast milk.

Metabolism/Excretion: Extensively metabolized by the liver; inactive metabolites excreted by the kidneys. Amount excreted unchanged by the kidneys depends on urine pH; as pH increases, amount excreted unchanged increases from 2–3% up to 80%.

Half-life: 2–3 hr for low doses; up to 15–30 hr with larger doses because of saturation of liver metabolism.

Time/Action Profile

(analgesia/fever reduction)

ROUTEONSETPEAKDURATION
PO5–30 min1–3 hr3–6 hr

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Derm: DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), rash, urticaria.

EENT: tinnitus.

GI: dyspepsia, epigastric distress, nausea, abdominal pain, anorexia, GI BLEEDING, hepatotoxicity, vomiting.

Hemat: anemia, hemolysis.
Misc: (INCLUDING ANAPHYLAXIS AND LARYNGEAL EDEMA)HYPERSENSITIVITY REACTIONS .

Interactions

Drug-Drug:

Drug-Natural Products:

Drug-Food:

Route/Dosage

see Calculator

Pain/Fever

Inflammation

Prevention of Transient Ischemic Attacks

Prevention of Myocardial Infarction/Antiplatelet Effects

Kawasaki Disease

Availability

(Generic available)

Assessment

Lab Test Considerations: Toxicity and Overdose:

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

Acuprin, Aspergum, Aspir-Low, Aspirtab, Bayer Aspirin, Bayer Timed-Release Arthritic Pain Formula, Easprin, Ecotrin, 8-Hour Bayer Timed-Release, Empirin, Halfprin, Healthprin, Norwich Aspirin, Sloprin, St. Joseph Adult Chewable Aspirin, Therapy Bayer, Vazalore, ZORprin

Canadian Brand Names

Asaphen, Entrophen, Lowprin, Novasen, Rivasa