BEERS REMS
Absorption: Well absorbed following oral administration.
Distribution: Unknown.
Protein Binding: 9699%.
Half-Life: 12 hr.
(plasma concentrations)
ROUTE | ONSET | PEAK* | DURATION |
---|---|---|---|
PO | unknown | 12 hr (1st); 45 hr (2nd) | 24 hr |
*Reflects effects of delayed release capsule.
Contraindicated in:
Use Cautiously in:
Derm: ACUTE GENERALIZED EXANTHEMATOUS PUSTULOSIS, cutaneous lupus erythematosus, DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), STEVENS-JOHNSON SYNDROME (SJS), TOXIC EPIDERMAL NECROLYSIS (TEN)
F and E: hypocalcemia (especially if treatment duration ≥3 mo), hypokalemia (especially if treatment duration ≥3 mo), hypomagnesemia (especially if treatment duration ≥3 mo)
GI: abdominal pain, diarrhea, CLOSTRIDIOIDES DIFFICILE-ASSOCIATED DIARRHEA (CDAD), flatulence, fundic gland polyps, nausea, vomiting
GU: acute tubulointerstitial nephritis
Hemat: vitamin B12 deficiency
MS: bone fracture
Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS, ANGIOEDEMA, OR ACUTE TUBULOINTERSTITIAL NEPHRITIS), systemic lupus erythematosus
Drug-drug:
Hepatic Impairment
Lab Test Considerations: