section name header

Pronunciation

floo-droe-KOR-ti-sone

Classifications

Therapeutic Classification: hormones

Pharmacologic Classification: corticosteroids (mineralocorticoid)

Indications

REMS


Unlabeled Use:

Action

  • Causes sodium reabsorption, hydrogen and potassium excretion, and water retention by its effects on the distal renal tubule.
Therapeutic effects:
  • Maintenance of sodium balance and BP in patients with adrenocortical insufficiency.

Pharmacokinetics

Absorption: Well absorbed following oral administration.

Distribution: Widely distributed to tissues.

Metabolism/Excretion: Mostly metabolized by the liver.

Half-Life: 3.5 hr.

Time/Action Profile

(mineralocorticoid activity)

ROUTEONSETPEAKDURATION
POunknownunknown1–2 days





Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: arrhythmias, edema, HF, hypertension

Endo: adrenal suppression

F and E: hypokalemia, hypokalemic alkalosis

GI: anorexia, nausea

Metab: weight gain

MS: arthralgia, muscular weakness, tendon contractures

Neuro: ascending paralysis, dizziness, headache

Misc: hypersensitivity reactions

Interactions

Drug-drug:

Route/Dosage

Availability

(Generic available)

Assessment

Lab Test Considerations:

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

Canadian Brand Names

Florinef