BEERS REMS
Absorption: >90% absorbed. Oral suspension results in 1537% higher serum concentrations compared to tablets. Bioavailability ↑ with food.
Distribution: Crosses the placenta; enters breast milk.
Protein Binding: >90%.
Half-Life: Spironolactone: 7884 min; Canrenone: 1324 hr.
Contraindicated in:
Use Cautiously in:
CV: arrhythmias
Derm: alopecia, DRUG RASH WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), pruritus, STEVENS-JOHNSON SYNDROME (SJS), TOXIC EPIDERMAL NECROLYSIS (TEN)
Endo: amenorrhea, breast tenderness, deepening of voice, gynecomastia (in males), ↑hair growth (in females), sexual dysfunction
F and E: hyperkalemia, hyponatremia, hyperchloremic metabolic acidosis
GI: GI irritation
GU: erectile dysfunction, dysuria
Hemat: agranulocytosis, thrombocytopenia
MS: muscle cramps
Drug-drug:
Oral suspension is not therapeutically equivalents to tablets. If patient requires a dose >100 mg, use tablets, NOT suspension. Suspension doses >100 mg may result in higher than expected spironolactone concentrations.
Hypertension
Edema
Primary Hyperaldosteronism
Acne (off-label use)
Hormone Therapy for Transgender Females (off-label use)
Lab Test Considerations: