REMS
Absorption: Rapidly absorbed from the GI tract.
Distribution: Concentrates in the thyroid gland.
Half-Life: 12 hr.
(effects on clinical thyroid status)
ROUTE | ONSET | PEAK | DURATION |
---|---|---|---|
PO | 1021 days‡ | 610 wk | wk |
‡Effects on serum thyroid hormone concentration may occur within 60 min of a single dose.
Contraindicated in:
Use Cautiously in:
CV: edema, vasculitis
Derm: rash, exfoliative dermatitis, hair loss, skin discoloration, STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS, urticaria
EENT: parotitis
Endo: hypothyroidism
GI: nausea, vomiting, diarrhea, HEPATOTOXICITY, loss of taste, splenomegaly
Hemat: AGRANULOCYTOSIS, APLASTIC ANEMIA, BLEEDING, leukopenia, thrombocytopenia
MS: arthralgia, myalgia
Neuro: drowsiness, headache, paresthesia, vertigo
Resp: interstitial pneumonitis
Misc: fever, lymphadenopathy
Drug-drug:
Lab Test Considerations: