section name header

Pronunciation

proo-KAL-o-pride

Classifications

Therapeutic Classification: prokinetic agents

Pharmacologic Classification: dihydrobenzofurancarboxamides

Indications

REMS


Action

  • Acts as a serotonin (5–HT4) receptor agonist with prokinetic properties. Enhances peristalsis and gastrointestinal propulsion.
Therapeutic effects:
  • Laxative effect.

Pharmacokinetics

Absorption: Rapidly absorbed (90%) following oral administration.

Distribution: Rapidly and extensively distributed, enters breast milk.

Metabolism/Excretion: 60% excreted unchanged in urine, 3–8% unchanged in feces, minor amounts are extensively metabolized.

Half-Life: 24 hr.

Time/Action Profile

(normalization of bowel movements)

ROUTEONSETPEAKDURATION
PO3–4 days1–4 wkunknown



Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CNS: headache, dizziness, fatigue

CV: PR interval, palpitations, tachycardia

GI: abdominal pain, diarrhea, nausea, vomiting

Interactions

Drug-drug:

Route/Dosage

Renal Impairment

Availability

Assessment

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

Canadian Brand Names

Resotran

Pronunciation

Classifications

Indications

Action

Pharmacokinetics

Time/Action Profile

Contraind./Precautions

Adv. Reactions/Side Effects

Interactions

Route/Dosage

Availability

Assessment

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

Canadian Brand Names