section name header

Pronunciation

klor-am-FEN-i-kole

Classifications

Therapeutic Classification: anti-infectives

Indications

REMS


Action

  • Inhibits protein synthesis in susceptible bacteria at the level of the 50S ribosome.
Therapeutic effects:
  • Bacteriostatic action.

Spectrum:

Pharmacokinetics

Absorption: IV administration results in complete bioavailabililty.

Distribution: Widely distributed to tissues. Crosses the blood-brain barrier with CSF levels 60% of serum values.

Metabolism/Excretion: Mostly metabolized by the liver; <10% excreted unchanged by the kidneys.

Half-Life: 1.5–3.5 hr.

Time/Action Profile

(plasma concentrations)

ROUTEONSETPEAKDURATION
IVrapidend of infusion6–12 hr





Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Derm: rash, urticaria

EENT: blurred vision, optic neuritis

GI: bitter taste, diarrhea, enterocolitis, glossitis, nausea, stomatitis, vomiting

Hemat: bone marrow depression, APLASTIC ANEMIA, neutropenia, thrombocytopenia

Neuro: confusion, delirium, depression, headache, peripheral neuritis

Misc: ANGIOEDEMA, fever, GRAY SYNDROME(IN NEWBORNS)

Interactions

Drug-drug:

Route/Dosage

Availability

(Generic available)

Assessment

Lab Test Considerations:

Toxicity and Overdose:

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

Canadian Brand Names

Chloromycetin