Therapeutic Classification: antivirals
Pharmacologic Classification: NS5A inhibitors, protease inhibitors
Glecaprevir
Absorption: Well absorbed following oral administration; absorption ↑ by high-fat meal.
Distribution: Unknown.
Protein Binding: 97.5%.
Half-Life: 6 hr.
Pibrentasvir
Absorption: Well absorbed following oral administration.
Distribution: Unknown.
Protein Binding: >99.9%.
Half-Life: 13 hr.
(plasma concentrations)
ROUTE | ONSET | PEAK | DURATION |
---|---|---|---|
glecaprevir (PO) | unknown | 5 hr | 24 hr |
pibrentasvir (PO) | unknown | 5 hr | 24 hr |
Contraindicated in:
Use Cautiously in:
Drug-drug:
Drug-Natural Products:
Lab Test Considerations: