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Pronunciation

strep-toe-MYE-sin

Classifications

Therapeutic Classification: anti-infectives

Pharmacologic Classification: aminoglycosides

Indications

REMS


Action

  • Inhibits protein synthesis in bacteria at level of 30S ribosome.
Therapeutic effects:
  • Bactericidal action.

Spectrum:

Pharmacokinetics

Absorption: Well absorbed after IM administration. Negligible absorption when administered orally.

Distribution: Widely distributed throughout extracellular fluid. Poor penetration into CSF.

Metabolism/Excretion: Excretion is >90% renal.

Half-Life: 2–4 hr ( in renal impairment).

Time/Action Profile

(plasma concentrations)
ROUTEONSETPEAKDURATION
IMrapid30–90 minN/A



All parenterally administered aminoglycosides.



Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

EENT: ototoxicity (vestibular and cochlear)

F and E: hypomagnesemia

GU: nephrotoxicity

MS: muscle paralysis (high parenteral doses)

Misc: hypersensitivity reactions

Interactions

Drug-drug:

Route/Dosage

Renal Impairment

Availability

(Generic available)

Assessment

Lab Test Considerations:

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes