section name header

Pronunciation

am-bri-SEN-tan

Classifications

Therapeutic Classification: antihypertensives

Pharmacologic Classification: endothelin receptor antagonists

Indications

REMS


Action

  • Antagonizes endogenous endothelin, resulting in vasodilation.
Therapeutic effects:
  • Improved exercise capacity and delayed clinical worsening; reduced hospitalizations (when used with tadalafil).

Pharmacokinetics

Absorption: Extent of absorption following oral administration unknown.

Distribution: Unknown.

Protein Binding: 99%.

Metabolism/Excretion: Highly metabolized.

Half-Life: 15 hr (effective half-life 9 hr).

Time/Action Profile

(plasma concentrations)

ROUTEONSETPEAKDURATION
POunknown2 hr24 hr





Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Interactions

Drug-drug:

Route/Dosage

Availability

(Generic available)

Assessment

Lab Test Considerations:

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

Letairis

Canadian Brand Names

Volibris