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Pronunciation

SEF-a-klor

Classifications

Therapeutic Classification: anti-infectives

Pharmacologic Classification: second generation cephalosporins

Indications

REMS


Action

  • Binds to bacterial cell wall membrane, causing cell death.
Therapeutic effects:
  • Bactericidal action against susceptible bacteria.

Spectrum:

Pharmacokinetics

Absorption: Well absorbed after oral administration.

Distribution: Widely distributed to tissues. Penetration into CSF is poor.

Metabolism/Excretion: Excreted primarily unchanged by the kidneys.

Half-Life: 30–60 min ( in renal impairment).

Time/Action Profile

ROUTEONSETPEAKDURATION
POrapid30–60 min6–12 hr
PO-CDunknownunknown12 hr





Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Interactions

Drug-drug:

Route/Dosage

Availability

(Generic available)

Assessment

Lab Test Considerations:

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes