Therapeutic Classification: anti-infectives
Pharmacologic Classification: second generation cephalosporins
REMS
Spectrum:
Absorption: Well absorbed after oral administration.
Distribution: Widely distributed to tissues. Penetration into CSF is poor.
Half-Life: 3060 min (↑ in renal impairment).
Contraindicated in:
Use Cautiously in:
GI: CLOSTRIDIOIDES DIFFICILE-ASSOCIATED DIARRHEA (CDAD), diarrhea, nausea, vomiting
Derm: rash, urticaria
Hemat: agranulocytosis, bleeding, eosinophilia, hemolytic anemia, neutropenia
Neuro: SEIZURES(VERY HIGH DOSES)
Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS AND SERUM SICKNESS), superinfection
Drug-drug:
Lab Test Considerations: