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Pronunciation

IN-soo-lin AS-spart

Classifications

Therapeutic Classification: antidiabetics, hormones

Pharmacologic Classification: pancreatics

Indications

BEERS REMS, High Alert


Action

  • Lowers blood glucose by:
    • stimulating glucose uptake in skeletal muscle and fat,
    • inhibiting hepatic glucose production.
  • Other actions of insulin:
    • inhibition of lipolysis and proteolysis,
    • enhanced protein synthesis.
  • A rapid-acting insulin with more rapid onset and shorter duration than human regular insulin; should be used with an intermediate- or long-acting insulin.
Therapeutic effects:
  • Control of hyperglycemia in patients with diabetes.

Pharmacokinetics

Absorption: Rapid acting.

Distribution: Identical to endogenous insulin.

Metabolism/Excretion: Metabolized by liver, spleen, kidney, and muscle.

Half-Life: Approximately 60–90 min.

Time/Action Profile

(hypoglycemic effect)

ROUTEONSETPEAKDURATION
SUBQwithin 15 min1–2 hr3–4 hr





Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Endo: HYPOGLYCEMIA

F and E: hypokalemia

Local: cutaneous amyloidosis, lipodystrophy, pruritus, erythema, swelling

Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS)

Interactions

Drug-drug:

Drug-Natural Products:

Route/Dosage

Availability

Assessment

Lab Test Considerations:

Toxicity and Overdose:

Implementation

IV Administration:

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

insulin aspart: Fiasp, Fiasp FlexTouch, Fiasp PenFill, NovoLOG, NovoLOG FlexPen, NovoLOG PenFill,

insulin aspart protamine suspension/insulin aspart injection mixture: NovoLOG Mix 70/30, NovoLOG Mix FlexPen

Canadian Brand Names

insulin aspart: NovoRapid,

insulin aspart protamine suspension/insulin aspart injection mixture: NovoMix 30