Therapeutic Classification: bone resorption inhibitors, electrolyte modifiers, hypocalcemics
Pharmacologic Classification: biphosphonates
REMS
Absorption: IV administration results in complete bioavailability.
Distribution: Concentrated in and binds to bone.
Half-Life: 167 hr.
Contraindicated in:
Use Cautiously in:
CV: hypotension, chest pain, leg edema
Derm: pruritus, rash, STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS
EENT: conjunctivitis
F and E: hypophosphatemia, hypocalcemia, hypokalemia, hypomagnesemia
GI: abdominal pain, constipation, diarrhea, nausea, vomiting, dysphagia
GU: ↓fertility (females), renal impairment/failure
Hemat: anemia
MS: musculoskeletal pain, femur fractures, osteonecrosis (primarily ONJ)
Neuro: agitation, anxiety, confusion, insomnia
Resp: asthma exacerbation
Drug-drug:
Paget's Disease
Treatment of Osteoporosis in Men or Postmenopausal Women or Treatment/Prevention of Glucocorticoid-Induced Osteoporosis
Prevention of Osteoporosis in Postmenopausal Women
Hypercalcemia of Malignancy
Multiple Myeloma or Bone Metastases from Solid Tumors
Lab Test Considerations:
IV Administration: