section name header

Pronunciation

GLYE-byoo-ride

Classifications

Therapeutic Classification: antidiabetics

Pharmacologic Classification: sulfonylureas

Indications

BEERS REMS

Action

Therapeutic Effects:

Pharmacokinetics

Absorption: Well absorbed following oral administration; micronized forms have better absorption.

Distribution: Reaches high concentrations in bile and crosses the placenta.

Metabolism/Excretion: Mostly metabolized by the liver, primarily by the CYP2C9 isoenzyme.

Half-life: 10 hr.

Time/Action Profile

(hypoglycemic activity)

ROUTEONSETPEAKDURATION
PO45–60 min1.5–3 hr24 hr

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Derm: photosensitivity, ERYTHEMA MULTIFORME, exfoliative dermatitis, rash.

Endo: hypoglycemia.

F and E: hyponatremia.

GI: constipation, cramps, diarrhea, dyspepsia, hepatitis, nausea, vomiting.

Hemat: agranulocytosis, APLASTIC ANEMIA, hemolytic anemia, leukopenia, pancytopenia, thrombocytopenia.

Metab: appetite, weight.

Neuro: dizziness, drowsiness, headache, weakness.

Interactions

Drug-Drug:

Route/Dosage

The nonmicronized formulation cannot be used interchangeably with the micronized formulation.

Availability

(Generic available)

Assessment

Lab Test Considerations: Toxicity and Overdose:

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

DiaBeta, Glynase

Pill Image

glyburide_195_8610.jpg