Therapeutic Classification: antihypertensives
Pharmacologic Classification: peripherally acting antiadrenergics
BEERS REMS
Absorption: 60% absorbed following oral administration.
Distribution: Widely distributed.
Protein Binding: 97%.
Half-Life: 23 hr.
(antihypertensive effects)
ROUTE | ONSET | PEAK | DURATION |
---|---|---|---|
PO | 2 hr | 24 hr‡ | 10 hr |
‡Following single dose; maximal antihypertensive effects occur after 34 wk of chronic dosing.
Contraindicated in:
Use Cautiously in:
CV: first-dose orthostatic hypotension, palpitations, angina, edema, syncope
EENT: blurred vision, intraoperative floppy iris syndrome
GI: abdominal cramps, diarrhea, dry mouth, nausea, vomiting
GU: erectile dysfunction, priapism
Neuro: dizziness, headache, weakness, depression, drowsiness
Drug-drug: