cefadroxil

Bind to bacterial cell wall membrane, causing cell death.

Therapeutic effects:

Bactericidal action against susceptible bacteria.

Spectrum:

Active against many gram-positive cocci including:
- Streptococcus pneumoniae,
- Group A beta-hemolytic streptococci,
- Penicillinase-producing staphylococci.
Not active against:
- Methicillin-resistant staphylococci,
- Bacteroides fragilis,
- Enterococcus.
Active against some gram-negative rods including:
- Klebsiella pneumoniae,
- Proteus mirabilis,
- Moraxella catarrhalis,
- Escherichia coli.

Pharmacokinetics ⬆ ⬇

Absorption: Well absorbed following oral administration.

Distribution: Widely distributed. Minimal CSF penetration.

Metabolism/Excretion: Excreted almost entirely unchanged by the kidneys.

Half-Life: 1–2 hr (↑ in renal impairment).

Time/Action Profile ⬆ ⬇

(plasma concentrations)

ROUTE	ONSET	PEAK	DURATION
PO	rapid	1.5–2 hr	12–24 hr

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Hypersensitivity to cephalosporins;
Serious hypersensitivity to penicillins.

Use Cautiously in:

Renal impairment (dose ↓ and/or ↑ dosing interval recommended if CCr ≤50 mL/min);
History of GI disease, especially colitis;
Geri: Dose adjustment due to age-related in renal function may be necessary in older adults.

Adv. Reactions/Side Effects ⬆ ⬇

GI: diarrhea, nausea, vomiting, CLOSTRIDIOIDES DIFFICILE-ASSOCIATED DIARRHEA (CDAD), dyspepsia

Derm: rash, pruritus, STEVENS-JOHNSON SYNDROME, urticaria

Hemat: agranulocytosis, thrombocytopenia

Neuro: SEIZURES(VERY HIGH DOSES)

Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS AND SERUM SICKNESS), superinfection

Interactions ⬆ ⬇

Drug-drug:

Probenecid ↓excretion and ↑ levels of renally excreted cephalosporins.
Concurrent use of loop diuretics or aminoglycosides may ↑ the risk of renal toxicity.

Route/Dosage ⬆ ⬇

PO (Adults ): Pharyngitis and/or tonsilitis: 500 mg every 12 hr or 1 g every 24 hr for 10 days. Skin and soft tissue infections: 500 mg every 12 hr or 1 g every 24 hr. Urinary tract infections: 500 mg–1 g every 12 hr or 1–2 g every 24 hr.
PO (Children ): Pharyngitis, tonsilitis, or impetigo: 15 mg/kg every 12 hr or 30 mg/kg every 24 hr for 10 days.Skin and soft tissue infections: 15 mg/kg every 12 hr.Urinary tract infections: 15 mg/kg every 12 hr.

Renal Impairment

PO (Adults ): CCr 25–50 mL/min: 500 mg every 12 hr; CCr 10–25 mL/min: 500 mg every 24 hr; CCr 0–10 mL/min: 500 mg every 36 hr.

Availability ⬆ ⬇

(Generic available)

Capsules: 500 mg
Tablets: 1 g
Oral suspension: 250 mg/5 mL; 500 mg/5 mL

Assessment ⬆ ⬇

Assess patient for infection (vital signs; appearance of wound, sputum, urine, and stool; WBC) at beginning of and throughout therapy.
Before initiating therapy, obtain a history to determine previous use of and reactions to penicillins or cephalosporins. Persons with a negative history of penicillin sensitivity may still have an allergic response.
Obtain specimens for culture and sensitivity before initiating therapy. First dose may be given before receiving results.
Observe patient for signs and symptoms of anaphylaxis (rash, pruritus, laryngeal edema, wheezing). Discontinue drug and notify physician or other health care professional immediately if these problems occur. Keep epinephrine, an antihistamine, and resuscitation equipment close by in case of an anaphylactic reaction.
Monitor bowel function. Diarrhea, abdominal cramping, fever, and bloody stools should be reported to health care professional promptly as a sign of CDAD. May begin up to several wk following cessation of therapy.
Assess patient for skin rash frequently during therapy. Discontinue at first sign of rash; may be life-threatening. Stevens-Johnson syndrome may develop. Treat symptomatically; may recur once treatment is stopped.

Lab Test Considerations:

May cause positive results for Coombs' test in patients receiving high doses or in neonates whose mothers were given cephalosporins before delivery.
- May cause ↑ serum AST, ALT, alkaline phosphatase, bilirubin, LDH, BUN, and creatinine.
- May rarely cause agranulocytosis, thrombocytopenia, and eosinophilia.

Implementation ⬆ ⬇

PO: Administer around the clock. May be administered on full or empty stomach. Administration with food may minimize GI irritation. Shake oral suspension well before administering. Refrigerate oral suspensions.

Patient/Family Teaching ⬆ ⬇

Instruct patient to take medication around the clock at evenly spaced times and to finish the medication completely as directed, even if feeling better. Missed doses should be taken as soon as possible unless almost time for next dose; do not double doses. Instruct patient to use calibrated measuring device with liquid preparations. Advise patient that sharing this medication may be dangerous.
Advise patient to report signs of superinfection (furry overgrowth on the tongue, vaginal itching or discharge, loose or foul-smelling stools) and allergy.
Instruct patient to notify health care professional if rash or fever and diarrhea develop, especially if diarrhea contains blood, mucus, or pus. Advise patient not to treat diarrhea without consulting health care professional.
Rep: Advise females of reproductive potential to notify health care professional if pregnancy is planned or suspected or if breastfeeding.

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Pronunciation ⬇

Classifications ⬆ ⬇

Indications ⬆ ⬇

Action ⬆ ⬇