REMS
Absorption: 59.4% absorbed following oral administration, rapidly converted to ganciclovir.
Distribution: Widely distributed to tissues, including CSF.
Half-Life: 4.1 hr (intracellular half-life of ganciclovir phosphate is 18 hr).
Contraindicated in:
Use Cautiously in:
GI: abdominal pain, diarrhea, nausea, vomiting
GU: ↓fertility, renal impairment
Hemat: anemia, aplastic anemia, bone marrow depression, NEUTROPENIA, pancytopenia, THROMBOCYTOPENIA
Neuro: headache, insomnia, agitation, ataxia, confusion, dizziness, hallucinations, paresthesia, peripheral neuropathy, psychosis, sedation, SEIZURES
Misc: fever, HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS), INFECTION
Drug-drug:
Treatment of CMV Disease
Renal Impairment
CCr 4059 mL/min
(Adults ): Induction: 450 mg twice daily for 21 days; Maintenance treatment or patients with inactive CMV retinitis: 450 mg once daily.Renal Impairment
CCr 2539 mL/min
(Adults ): Induction: 450 mg once daily for 21 days; Maintenance treatment or patients with inactive CMV retinitis: 450 mg every 2 days.Renal Impairment
CCr 1024 mL/min
(Adults ): Induction: 450 mg every 2 days for 21 days; Maintenance treatment or patients with inactive CMV retinitis: 450 mg twice weekly.Prevention of CMV Disease in Transplant Patients
Renal Impairment
Lab Test Considerations: