REMS
Absorption: Well absorbed following oral administration.
Distribution: Widely distributed; high tissue concentrations achieved. Crosses the placenta, enters breast milk.
Half-Life: 35 days.
Contraindicated in:
Use Cautiously in:
CV: ECG changes (T-wave abnormalities, QRS prolongation), cardiomyopathy, hypotension
Derm: alopecia, dermatoses, photosensitivity, pigmentary changes, pruritus, skin eruptions, STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS, urticaria
EENT: corneal opacities (reversible), hearing impairment, retinopathy, tinnitus, visual disturbances
GI: ↑liver enzymes, abdominal cramps, anorexia, diarrhea, hepatitis, nausea, vomiting
Hemat: AGRANULOCYTOSIS, APLASTIC ANEMIA, LEUKOPENIA, thrombocytopenia
Neuro: agitation, anxiety, confusion, delirium, depression, extrapyramidal reactions, hallucinations, headache, insomnia, neuromyopathy, peripheral neuritis, personality changes, polyneuritis, psychosis, SEIZURES, weakness
Drug-drug:
Suppression/Prophylaxis of Malaria
Treatment of Acute Attack of Malaria
Extraintestinal Amebiasis
Rheumatoid Arthritis/Systemic Lupus Erythematosus
Lab Test Considerations: