REMS
Absorption: Minimal absorption, action is primarily in GI tract.
Distribution: Minimal systemic distribution.
Half-Life: Unknown.
Contraindicated in:
Use Cautiously in:
CV: hypotension, peripheral edema, syncope
GI: diarrhea, nausea, abdominal distention, abdominal pain, dry mouth, dyspepsia, reflux, vomiting
MS: arthralgia
Resp: dyspnea
Drug-drug:
Chronic Idiopathic Constipation and Opioid-Induced Constipation
Hepatic Impairment
Irritable Bowel Syndrome with Constipation
Hepatic Impairment