anesthetics (topical/mucosal)

benzocaine: BEN-zoe-kane

dibucaine: DYE-byoo-kane

dyclonine: DYE-klon-een

pramoxine: pra-MOX-een

Classifications ⬆ ⬇

Therapeutic Classification: anesthetics (topical/local)

Indications ⬆ ⬇

High Alert

Relief of pruritus or pain associated with minor skin disorders including burns, abrasions, bruises, insect stings/bites, dermatitis, hemorrhoids, or other forms of skin irritation.

Mucosal

Provide local anesthesia to mucosal surfaces before instrumentation, minor procedures, or endoscopy. Decrease irritation caused by minor mouth and throat conditions including sore throat, gingivitis, stomatitis, or teething. Also used to suppress the gag reflex during endoscopy or intubation.

Action ⬆ ⬇

Inhibit initiation and conduction of sensory nerve impulses.

Therapeutic effects:

Local anesthesia with subsequent loss of sensation or relief of pain and/or pruritus.

Pharmacokinetics ⬆ ⬇

Absorption: Benzocaine is poorly absorbed through intact skin. Other agents may be readily absorbed. Degree of absorption ↑ with surface area; presence of lesions, cuts, or abrasions; and amount of agent applied.

Distribution: Unknown.

Metabolism/Excretion: Ester-type agents (PABA derivatives, benzocaine) are metabolized by plasma and liver cholinesterases. Small amounts of amide-type agents (dibucaine) that may be absorbed are mostly metabolized by the liver.

Half-Life: Unknown.

Time/Action Profile ⬆ ⬇

(mucosal anesthetic effects)

ROUTE	ONSET	PEAK	DURATION
Benzocaine	about 1 min	unknown	15–20 min
Dibucaine	within 15 min	unknown	2–4 hr
Dyclonine	up to 10 min	unknown	60 min
Pramoxine	3–5 min	unknown	unknown

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Hypersensitivity. Cross-sensitivity may occur among related agents (amide types—dibucaine; ester types—benzocaine, tetracaine);
Hypersensitivity to any components of preparations including stabilizers, colorants, or bases;
Active, untreated infection of affected area;
Not to be used in the eye;
Some products contain alcohol and should be avoided in patients with known alcohol intolerance;
Pedi: Topical benzocaine products should not be used in children 2 yr.

Use Cautiously in:

Debilitated patients;
Large or severely abraded areas of skin or mucous membrane;
Prolonged use (not recommended);
Pedi: risk of systemic toxicity, safety not established for some products; use smaller doses due to potential for methemoglobinemia;;
Geri: risk of toxicity; use smaller doses.

Adv. Reactions/Side Effects ⬆ ⬇

EENT:

mucosal use

↓or absent gag reflex

Derm:

topical use

burning, edema, irritation, stinging, tenderness, urticaria

Misc: ANAPHYLAXISALLERGIC REACTIONS INCLUDING

Interactions ⬆ ⬇

Drug-drug:

Toxicity of ester-type agents may be increased by concurrent use of cholinesterase inhibitors.

Route/Dosage ⬆ ⬇

Benzocaine

Topical/Mucosal
(Adults and Children ): Apply cream, ointment, topical solutions, or dental/oral products as needed. Lozenges may be used hourly (not to exceed 12 lozenges/day). Rectal products may be used twice daily.

Dibucaine

(Adults and Children ): Apply as needed (not to exceed 30 g/day in adults or 7.5 g/day in children). Can be used 3–4 times daily.

Dyclonine

Mucosal
(Adults ): 2- or 3-mg lozenge may be dissolved in the mouth q 2 hr (not to exceed 10 lozenges/day), or solution may be used 4 times daily.
Mucosal
(Children ≥2 yr): 1.2-mg lozenge may be dissolved in mouth q 2 hr (not to exceed 10 lozenges/day).

Pramoxine

Topical/Mucosal
(Adults ): Topical products may be used q 3 hr as needed. Rectal products may be used up to 5 times daily.

Availability ⬆ ⬇

Benzocaine

Lozenges: 6 mg^OTC; 10 mg^OTC; 15 mg^OTC; 18 mg^OTC
Oral ointment: 20%^OTC
Oral paste: 20%^OTC
Oral swab: 7.5%^OTC; 20%^OTC
Topical swab: 20%^OTC
Rectal ointment: 20%^OTC
Oral gel: 6.5%^OTC; 7.5%^OTC; 10%^OTC; 15%^OTC; 20%^OTC
Oral cream: 20%^OTC
Oral liquid: 6.3%^OTC
Oral aerosol: 20%^OTC
Topical aerosol: 20%^OTC
Topical cream: 6%^OTC; 20%^OTC
Topical gel: 7.5%^OTC; 10%^OTC; 20%^OTC
Topical ointment: 5%^OTC; 6%^OTC; 20%^OTC
Topical solution: 2%^OTC; 5%^OTC; 20%^OTC
In combination with: butamben and tetracaine (Cetacaine), and phenolOTC. See Appendix [not included in this PDA edition].

Dibucaine

Topical ointment: 1%^OTC

Dyclonine

Lozenges: 1.2 mg^OTC; 2 mg^OTC; 3 mg^OTC

Pramoxine

Topical cream: 1%^OTC
Topical gel: 1%^OTC
Topical solution: 1%^OTC
Topical spray: 1%^OTC
Rectal aerosol foam: 1%^OTC
Rectal ointment: 1%^OTC
In combination with: hydrocortisone (Analpram HC, Pramosome, ProctoFoam HC). See Appendix [not included in this PDA edition].

Assessment ⬆ ⬇

Assess type, location, and intensity of pain before and a few minutes after administration of anesthetic.
Assess integrity of involved skin and mucous membranes before and periodically throughout course of therapy. Notify health care professional if signs of infection or irritation develop.

Implementation ⬆ ⬇

Overuse of topical anesthetic sprays on mucous membranes can result in methemoglobinemia. Avoid overuse or too liberal application.
Alcohol-free preparation is available for teething pain in babies. Apply to gums by rubbing gel on with fingers or cotton swab.
Throat Spray: Ensure that gag reflex is intact before allowing patient to drink or eat.

Patient/Family Teaching ⬆ ⬇

Instruct patient on correct application technique.
Inform patient of potential harm from overuse.
Emphasize need to avoid contact with eyes.
- Caution patient that these agents should not be applied for prolonged periods or to large areas, especially if skin is abraded or broken, without consulting health care professional. Patient should also consult health care professional before using these agents for conditions other than indicated.
- Advise patient to discontinue use and notify health care professional if erythema, rash, or irritation at site of administration occurs; area becomes infected; medication is swallowed; or condition worsens or does not improve within 7 days.
- Caution patient to read list of active ingredients on OTC products. Brand names frequently change and may be misleading as to actual contents.
- Advise adults using liquid form around the mouth to avoid smoking until solution is dry.
Teething Gel: Instruct patients to notify health care professional if pain is excessive or prolonged. Advise parents to avoid feeding immediately after application to prevent choking from diminished gag reflex.
Lozenge: Instruct patient to suck on lozenge and allow it to slowly dissolve. Consult health care professional if throat pain persists more than 2 days. Avoid use in young children because of danger of choking.

Evaluation/Desired Outcomes ⬆ ⬇

Temporary relief of discomfort associated with minor irritations of skin or mucous membranes.
Temporary local anesthesia of mucosal surfaces.

US Brand Names ⬆ ⬇

benzocaine: Americaine Hemorrhoidal, Anbesol, Anbesol Baby, Anbesol Cold Sore Therapy, Anbesol Jr., Anbesol Maximum Strength, Benzodent, Cepacol Sore Throat Pain Relief, Dentapaine, Dermoplast Pain Relieving, Hurricaine, Lanacane, Orajel Mouth Sore, Orabase, Medicone Hemorrhoidal, Mycinettes, Zilactin-B,

dibucaine: Nupercainal,

dyclonine: Sucrets Children's, Sucrets Maximum Strength, Sucrets Regular Strength,

pramoxine: Caladryl Clear, ProctoFoam NS, Sarna Ultra, Tronolane, Tucks Hemorrhoidal

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Pronunciation ⬇