section name header

Pronunciation

e-TRA-veer-een

Classifications

Therapeutic Classification: antiretrovirals

Pharmacologic Classification: non nucleoside reverse transcriptase inhibitors

Indications

REMS


Action

  • Binds to the enzyme reverse transcriptase, which results in disrupted viral DNA synthesis.
Therapeutic effects:
  • Evidence of decreased viral replication and reduced viral load with slowed progression of HIV and its sequelae.

Pharmacokinetics

Absorption: Well absorbed following oral administration. Food enhances absorption.

Distribution: Unknown.

Protein Binding: 99.9%.

Metabolism/Excretion: Mostly metabolized by the liver (CYP3A4, CYP2C9, and CYP2C19 isoenzymes); minimal renal excretion; mostly eliminated in feces as unchanged drug and metabolites.

Half-Life: 41 hr.

Time/Action Profile

(blood levels)

ROUTEONSETPEAKDURATION
POunknown2.5–4 hr12 hr





Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Interactions

Drug-drug:

Drug-Natural Products:

Route/Dosage

Availability

(Generic available)

Assessment

Lab Test Considerations:

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes

US Brand Names

Intelence