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Pronunciation

FOE-lik A -sid

Classifications

Therapeutic Classification: antianemics, vitamins

Pharmacologic Classification: water soluble vitamins

Indications

REMS

Action

Therapeutic Effects:

Pharmacokinetics

Absorption: Well absorbed from the GI tract and IM and SUBQ sites.

Distribution: Half of all stores are in the liver. Enters breast milk. Crosses the placenta.

Protein Binding: Extensive.

Metabolism/Excretion: Converted by the liver to its active metabolite, dihydrofolate reductase. Excess amounts are excreted unchanged by the kidneys.

Half-life: Unknown.

Time/Action Profile

( in reticulocyte count)

ROUTEONSETPEAKDURATION
PO, IM, SUBQ, IV30–60 min1 hrunknown

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

Derm: rash.

Neuro: confusion, difficulty sleeping, irritability, malaise.
Misc: fever.

Interactions

Drug-Drug:

Route/Dosage

see Calculator

Therapeutic Dose (Folic acid deficiency)

Recommended Daily Allowance

Availability

(Generic available)

Assessment

Lab Test Considerations:

Implementation

Patient/Family Teaching

Evaluation/Desired Outcomes