doe-BYOO-ta-meen
High Alert
Absorption: IV administration results in complete bioavailability.
Distribution: Unknown.
Half-Life: 2 min.
Contraindicated in:
Use Cautiously in:
CV: hypertension, premature ventricular contractions, tachycardia, angina, arrhythmias, hypotension, palpitations
Local: phlebitis
Neuro: headache
Resp: dyspnea
Misc: hypersensitivity reactions, nonanginal chest pain
Drug-drug:
Lab Test Considerations:
IV Administration:
Dobutamine is a vesicant. Administer into a large vein. If extravasation occurs, immediately stop infusion. Leave needle/cannula in place temporarily but do not flush the line. Gently aspirate extravasated solution; then remove needle/cannula. Elevate patient's extremity and apply dry warm compresses. Initiate phentolamine antidote for refractory cases in addition to supportive management. For phentolamine, dilute 5–10 mg in 10 mL of 0.9% NaCl and administer SUBQ into extravasation site as soon as possible after extravasation; if IV catheter remains in place, administer initial dose IV through the infiltrated catheter. May repeat in 60 min if patient remains symptomatic. Nitroglycerin 2% topical ointment (1-inch strip applied to site of ischemia to cover affected area; may repeat every 8 hr as necessary) or terbutaline (dilute 1 mg in 10 mL of 0.9% NaCl and administer SUBQ into extravasation site; may repeat in 15 min if necessary) may be used as alternatives to phentolamine.