Secondarily infected traumatic skin lesions (up to 10 cm in length or 100 cm2 area).
Action⬆⬇
Inhibits bacterial protein synthesis.
Therapeutic effects:
Inhibition of bacterial growth and reproduction.
Spectrum:
Greatest activity against gram-positive organisms, including:
Staphylococcus aureus,
Streptococcus pyogenes.
Pharmacokinetics⬆⬇
Absorption: Minimal systemic absorption.
Distribution: Remains in the stratum corneum after topical use for prolonged periods of time (72 hr).
Metabolism/Excretion: Metabolized in the skin; removed by desquamation.
Half-Life: 17–36 min.
Time/Action Profile⬆⬇
(anti-infective effect)
ROUTE
ONSET
PEAK
DURATION
Topical‡
unknown
3–5 days
72 hr
‡Resolution of lesions.
Contraind./Precautions⬆⬇
Contraindicated in:
Hypersensitivity to mupirocin or polyethylene glycol.
Use Cautiously in:
Renal impairment;
Burn patients.
Adv. Reactions/Side Effects⬆⬇
Derm: burning, itching, pain, stinging
Interactions⬆⬇
Drug-drug:
None reported.
Route/Dosage⬆⬇
(Adults and Children ≥2 mo): Ointment: Apply 3–5 times daily for 5–14 days.
(Adults and Children ≥3 mo): Cream: Apply small amount 3 times/day for 10 days.
Availability⬆⬇
(Generic available)
Cream: 2%
Ointment: 2%
Assessment⬆⬇
Assess lesions before and daily during therapy for efficacy.
Monitor for signs and symptoms of hypersensitivity reaction, including anaphylaxis, urticaria, angioedema, generalized rash, or local irritation. If severe hypersensitivity reaction occurs, discontinue therapy, treat as clinically indicated, and institute alternative therapy for infection.
Monitor for microbial overgrowth of nonsusceptible microorganisms, including fungi.
Implementation⬆⬇
Topical Wash affected area with soap and water and dry thoroughly. Apply a small amount of mupirocin using a cotton swab or gauze to affected area 3 times daily and rub in gently. Treated area may be covered with gauze if desired. Do not apply to mucosa or concurrently with other lotions, creams, or ointments.
Patient/Family Teaching⬆⬇
Explain purpose and side effects of medication. Advise patient to read Patient Information before starting therapy.
Instruct patient on correct application procedure, as well as appropriate hygienic measures to prevent spread of impetigo. If a dose is missed, apply as soon as possible unless almost time for next dose. Avoid contact with eyes.
Advise patient to notify health care provider of all Rx, OTC or topical medications, vitamins, or herbal products being taken and to consult health care provider before taking other medications.
Advise patient to immediately notify health care provider if swelling of lips, face, or tongue or wheezing occurs.
Advise patient to stop mupirocin and notify health care provider if local reaction (irritation, severe itching, rash) occurs.
Rep: Advise women of reproductive potential to notify health care provider if pregnancy is planned or suspected or if breastfeeding. To minimize oral exposure to child, a breast treated with mupirocin should be thoroughly washed prior to breastfeeding.
Evaluation/Desired Outcomes⬆⬇
Healing of skin lesions. If no clinical response is seen in 3–5 days, condition should be re-evaluated.
