Topical Primary and secondary bacterial skin infections, including impetigo contagiosa, erythrasma, and secondary skin infections such as infected wounds/burns.
Superficial eye infections.
Action⬆⬇
Inhibits bacterial protein synthesis.
Therapeutic effects:
Resolution of localized bacterial infections.
Spectrum:
Greatest activity against gram-positive organisms, including:
Staphylococcus aureus,
Streptococcus pyogenes.
Corynebacterium spp.
Pharmacokinetics⬆⬇
Absorption: Unknown.
Distribution: Unknown.
Metabolism/Excretion: Absorbed drug is extensively metabolized.
Half-Life: 5–6 hr.
Time/Action Profile⬆⬇
ROUTE
ONSET
PEAK
DURATION
Top
unknown
unknown
6–8 hr
Ophth
unknown
unknown
12 hr
Contraind./Precautions⬆⬇
Contraindicated in:
Hypersensitivity to fusidic acid or other components of the formulation (topical ointment contains lanolin).
Use Cautiously in:
OB: Use during pregnancy only if potential maternal benefit justifies potential fetal risk;
Lactation: Safety and effectiveness not established in breastfeeding;
Pedi: Ophthalmic formulation not indicated for use in neonatal conjunctivitis.
Adv. Reactions/Side Effects⬆⬇
Derm: mild local irritation
Interactions⬆⬇
Drug-drug:
None reported.
Route/Dosage⬆⬇
(Adults and Children ): Apply to affected area 3–4 times daily.
(Adults and Children ): One drop into conjunctival sac of both eyes every 12 hr for 7 days.
Assess involved areas of skin and mucous membranes before and frequently during therapy. ↑ skin irritation may indicate need to discontinue medication.
Implementation⬆⬇
Do not confuse topical product with ophthalmic product.
Topical Consult health care provider for proper cleansing technique before applying medication. Apply small amount to cover affected area completely. Avoid the use of occlusive wrappings or dressings unless directed by health care provider.
Contact lenses should not be worn during treatment. Administer 1 drop into conjunctival sac of both eyes every 12 hr for 7 days. See Medication Administration Techniques for instructions.
Patient/Family Teaching⬆⬇
Explain purpose and side effects of medication to patient. Advise patient to read Patient Information before starting therapy. Advise to apply medication as directed for full course of therapy, even if feeling better.
Advise patient to notify health care provider of all Rx or OTC medications, vitamins, or herbal products being taken and to consult with health care provider before taking other medications.
Advise patient to report ↑ skin irritation or lack of response to therapy to health care provider.
Rep: Advise women of reproductive potential to notify health care provider if pregnancy is planned or suspected or if breastfeeding.