bimatoprost (lash, ophthalmic)

Absorption: Minimal systemic absorption.

Distribution: Small amounts absorbed are widely distributed.

Metabolism/Excretion: Highly metabolized; 67% excreted in urine, 25% in feces mostly as metabolites.

Half-Life: 45 min.

Time/Action Profile ⬆ ⬇

(improvement in eyelash growth)

ROUTE	ONSET	PEAK	DURATION
Topical	2 mos	4 mos	4 wk or more*

*Following discontinuation.

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Hypersensitivity.

Use Cautiously in:

Active intraocular inflammation;
Patients with aphakia, pseudoaphakia with a torn posterior lens capsule, or know risk factors for macular edema;
OB: Use only if potential benefit justifies potential risk to the fetus;
Lactation: Use cautiously;
Pedi: Limited data.

Adv. Reactions/Side Effects ⬆ ⬇

EENT: conjunctival hyperemia, dry eye, eye pruritus, hyperpigmentation of eyelids, macular edema, periorbital erythema, permanent pigmentation of the iris

Misc: hypersensitivity reactions

Interactions ⬆ ⬇

Drug-drug:

May ↓ the intraocular pressure lowering effect of prostaglandin analogs.

Route/Dosage ⬆ ⬇

(Adults ): Apply to upper eyelid margin nightly.

Availability ⬆ ⬇

(Generic available)

Ophthalmic solution: 0.3 mg/mL

Assessment ⬆ ⬇

Monitor intraocular pressure in patients with a history of increased intraocular pressure or who are using prostaglandin analogs for intraocular pressure reduction concurrently.

Implementation ⬆ ⬇

Topical Apply once each night using the accompanying sterile applicators. Additional applications will not increase growth of eyelashes.

Patient/Family Teaching ⬆ ⬇

Instruct patient on correct application of bimatoprost. If a dose is missed, omit and apply next evening; do not double dose. Patient should wash face and remove all makeup and contact lenses prior to application. May discolor soft contact lenses. Contact lenses may be reinserted 15 min following application. Place one drop of medication on the disposable sterile applicator and brush cautiously along the skin of the upper eyelid margin at the base of the eyelashes. Use only the applicator supplied with the product. Use each applicator for one eye then discard; reuse may result in contamination and infection. If solution gets into the eye, it is not harmful and does not need to be rinsed. Do not apply to lower lash line. Blot any excess solution outside upper eyelid margin with a tissue or other absorbent material. Do not allow tip of bottle or applicator to come in contact with surrounding structures, fingers, or any other unintended surface to avoid contamination. Instruct patient to read the Patient Information guide prior to use and with each Rx refill, in case of new information.
Inform patient that may cause increased brown pigmentation of colored part of eye (iris) which is likely to be permanent. Eyelid skin may darken with use of bimatoprost; may be reversible with discontinuation of medication.
Inform patient of potential for hair growth occurring outside target treatment area if medication repeatedly touched same area of skin.
Advise patient to notify health care professional immediately if eye trauma or infection, sudden decrease in visual acuity, conjunctivitis, or eyelid reactions occur or if having ocular surgery.
Instruct patient to notify health care professional of bimatoprost use prior to intraocular pressure examinations.
Advise female patients to notify health care professional if pregnancy is planned or suspected or if breastfeeding.

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Pronunciation ⬇

Classifications ⬆ ⬇

Indications ⬆ ⬇

Action ⬆ ⬇

Pharmacokinetics ⬆ ⬇