PO (Adults ): 8.4 g once daily; titrate dose at ≥1 wk intervals by 8.4 g once daily as needed to achieve desired serum potassium concentration (max = 25.2 g once daily).
PO (Children ≥12 yr): 4 g once daily; titrate dose at ≥1 wk intervals by 4 g once daily as needed to achieve desired serum potassium concentration (max = 25.2 g once daily).
Monitor for bowel sounds and frequency and consistency of stools periodically during therapy. May cause constipation.
Lab Test Considerations:
Monitor serum potassium and magnesium periodically during therapy. May cause hypokalemia and hypomagnesemia. Consider magnesium supplements if hypomagnesemia occurs.
Implementation⬆⬇
Due to delayed action, do not use patiromer as an emergency treatment of life-threatening hyperkalemia.
PO: Administer immediately ≥3 hr before or 3 hr after other PO medications. Measure ⅓ cup of water. Pour half the water into a glass; then add patiromer and stir. Add the remaining half of the water and stir thoroughly. The powder will not dissolve and mixture will look cloudy. Add more water to the mixture as needed for desired consistency. Drink mixture immediately. If powder remains in the glass after drinking, add more water, stir, and drink immediately. Repeat as needed to ensure the entire dose is administered. May use other beverages or soft foods (applesauce, yogurt, pudding) instead of water to prepare mixture. Do not heat or add to heated foods or liquids. Do not take in dry form. Stable for 3 mo at room temperature or until the packet expiration date if refrigerated.
Patient/Family Teaching⬆⬇
Instruct patient to take patiromer as directed and adhere to prescribed diet.
Advise patient to take patiromer ≥3 hr before or 3 hr after other medications.
Instruct patient to not heat suspension or add to heated foods or liquids. Do not take in dry form.
Rep: Advise females of reproductive potential to notify health care professional if pregnancy is planned or suspected or if breastfeeding. Patiromer is not absorbed systemically, so it is not expected to harm fetus.
