- Deoxycholate and lipid-based formulations are NOT interchangeable.
Amphotericin Deoxycholate
- IV (Adults ): Give test dose of 1 mg. If test dose tolerated, initiate therapy with 0.25 mg/kg/day (doses up to 1.5 mg/kg/day may be used, depending on type of infection) (alternate-day dosing may also be used); Bladder irrigation: Instill 50 mcg/mL solution into bladder daily for 5–10 days.
- IV (Infants and Children): Give test dose of 0.1 mg/kg (maximum dose 1 mg) or may administer initial dose of 0.25–1 mg/kg/day over 6 hr (without test dose) (some infections may require 1.5 mg/kg/day; alternate-day dosing may be used).
- IT (Adults ): 25–300 mcg every 48–72 hr; ↑ to 500 mcg–1 mg as tolerated (maximum total dose = 15 mg).
- IT (Children ): 25–100 mcg every 48–72 hr; ↑ to 500 mcg as tolerated.
Amphotericin B Lipid Complex (Abelcet)
- IV (Adults and Children ): 2.5–5 mg/kg every 24 hr (no test dose needed).
Amphotericin B Liposome (AmBisome)
- IV (Adults and Children ): Empiric therapy: 3 mg/kg every 24 hr; Documented infections: 3–5 mg/kg every 24 hr; Visceral leishmaniasis (immunocompetent patients): 3 mg/kg every 24 hr on days 1–5; then 3 mg/kg every 24 hr on days 14 and 21; Visceral leishmaniasis (immunosuppressed patients): 4 mg/kg every 24 hr on days 1–5; then 4 mg/kg every 24 hr on days 10, 17, 24, 31, and 38; Cryptococcal meningitis in HIV patients: 6 mg/kg every 24 hr.