Active components of senna (sennosides) alter water and electrolyte transport in the large intestine, resulting in accumulation of water and increased peristalsis.
Therapeutic effects:
Laxative action.
Pharmacokinetics⬆⬇
Absorption: Minimally absorbed following oral administration.
Larger doses have been used to treat/prevent opioid-induced constipation. Consult labeling of individual OTC products for more specific dosing information.
PO (Adults ): 17.2–50 mg 1–2 times daily.
PO (Children 12–17 yr): 17.6–26.4 mg 1–2 times daily
PO (Children 6–11 yr): 8.8–13.2 mg 1–2 times daily.
Assess for abdominal distention, presence of bowel sounds, and usual pattern of bowel function.
Assess color, consistency, and amount of stool produced.
Implementation⬆⬇
PO: Take with 8 ounces of water. Administer at bedtime for evacuation 6–12 hr later. Administer on an empty stomach for more rapid results.
Shake oral solution well before administering.
Patient/Family Teaching⬆⬇
Explain purpose and side effects of medication to patient. Advise patient to read Patient Information before starting therapy.
Advise patient to notify health care provider of all Rx or OTC medications, vitamins, or herbal products being taken and to consult with health care provider before taking other medications.
Advise patient that laxatives should be used only for short-term therapy. Long-term therapy may cause electrolyte imbalance and dependence.
Encourage patient to use other forms of bowel regulation, such as ↑ fluid intake and fiber in the diet, and ↑ mobility. Normal bowel habits are individualized and may vary from 3 times/day to 3 times/wk.
Inform patient that this medication may cause a change in urine color to pink, red, violet, yellow, or brown.
Instruct patients with cardiac disease to avoid straining during bowel movements (Valsalva maneuver).
Advise patient not to use laxatives when abdominal pain, nausea, vomiting, or fever is present.
Rep: Advise women of reproductive potential to notify health care provider if pregnancy is planned or suspected or if breastfeeding.