SC (Adults and Children ≥6 yr): 0.6 mg initially; may repeat in 15 min if no response using a new device.
Availability⬆⬇
Solution for injection (prefilled syringes and autoinjectors): 0.6 mg/0.6 mL
Assessment⬆⬇
Assess BP after administration. If substantial ↑ BP occurs,consider undiagnosed pheochromocytoma and provide appropriate medical intervention, which may include phentolamine.
Monitor for generalized rash and signs of anaphylaxis. If serious hypersensitivity reaction occurs,stop dasiglucagon and provide appropriate medical intervention.
Assess for preexisting malnutrition, adrenal insufficiency, and chronic hypoglycemia. Patients in these states may not have adequate hepatic glycogen; treat alternatively with glucose.
Lab Test Considerations:
Monitor plasma glucose after administration as clinically indicated. If severe or continued hypoglycemia occurs,administer oral or IV glucose and consider undiagnosed insulinoma.
Monitor serum potassium after administration, as large doses of dasiglucagon may cause a ↓ in levels.
Implementation⬆⬇
Administer supplemental carbohydrates IV or orally to facilitate ↑ serum glucose levels.
SC: Single-dose autoinjector and single-dose prefilled syringe solutions are clear and colorless; do not administer if solution is discolored or contains particulates. Store refrigerated in protective case away from light. Expires after 12 mo at room temperature or packet expiration date, whichever comes first. Inject in outer upper arm, lower abdomen, front or back of thigh, or buttock.
Patient/Family Teaching⬆⬇
Explain purpose and side effects of medication to patient. Advise patient to read Patient Information before starting therapy.
Teach patient about recognition of hypoglycemia and risks of prolonged hypoglycemia. Educate family, friends, and caregivers regarding these signs and on how to administer dasiglucagon and where it is kept. After each administration, a health care professional must be immediately contacted.
Advise patient that once food or drink may be consumed safely, fast-acting (juice) and long-acting (crackers with cheese) sources of sugar should be given.
Explain signs and symptoms of hypersensitivity reactions to patient and advise them to immediately seek medical care if difficulty breathing or significant dizziness occur.
Instruct patient to check expiration date monthly and to replace outdated medication immediately.
Review reasons for carrying sources of sugar, medical identification, and treatment regimen at all times with patients with diabetes mellitus.
Advise patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult health care professional before taking other medications.
Rep: Advise females of reproductive potential to notify health care professional if pregnancy is planned or suspected or if breastfeeding.
