Bumetanide
- PO (Adults ): 0.5–2 mg/day as a single dose. Up to 2 additional doses may be given during the day every 4–5 hr (up to 10 mg/day). Alternate-day or every-2–3-day regimens may also be used.
- IM IV (Adults ): 0.5–1 mg; may be repeated every 2–3 hr as needed (up to 10 mg/day).
Furosemide
- PO (Adults ): Edema: 20–80 mg/day as a single dose initially; may repeat in 6–8 hr; may ↑ dose by 20–40 mg every 6–8 hr until desired response. Maintenance doses may be given once or twice daily or intermittently for 2–4 days/wk (doses up to 2.5 g/day have been used in patients with HF or renal disease). Hypertension: 40 mg twice daily initially (when added to regimen, ↓ dose of other antihypertensives by 50%); adjust further dosing based on response; Hypercalcemia: 120 mg/day in 1–3 doses.
- PO (Children ): 2 mg/kg as a single dose; may ↑ by 1–2 mg/kg every 6–8 hr (1–2 mg/kg/day initially, up to 5–6 mg/kg/day). Longer dosage intervals are recommended in neonates.
- IM IV (Adults ): Edema: 20–40 mg; may repeat in 2 hr and ↑ by 20 mg every 2 hr until response is obtained; maintenance dose may be given once or twice daily; Acute pulmonary edema: 40 mg; after 1 hr may give additional 80 mg (in HF and renal failure, daily doses of up to 2.5 g have been used); Hypercalcemia: 80–120 mg; may repeat every 1–4 hr; titrate by response.
- IM IV (Children ): 1 mg/kg; may ↑ by 1 mg/kg every 2 hr (not to exceed 6 mg/kg).
- IM IV (Neonates ): 1–2 mg/kg/dose every 12–24 hr.
- SUBQ (Adults ): 30 mg over the 1st hr, then 12.5 mg per hr over the next 4 hr with the single-use on-body infusor. Replace with oral diuretic therapy as soon as possible.
Torsemide
- PO (Adults ): HF: Generic or Sooanz: 20 mg once daily; may double dose until desired effect obtained (max = 200 mg/day). Chronic renal failure: Generic or Soaanz: 20 mg once daily; may double dose until desired effect obtained (max = 200 mg/day). Hepatic cirrhosis: Generic only: 5–10 mg once daily (with aldosterone antagonist or potassium-sparing diuretic); may double dose until desired effect obtained (max = 40 mg/day). Hypertension: 5 mg once daily; may ↑ to 10 mg once daily after 4–6 wk (if still not effective, add another agent).