tivozanib

Absorption: Well absorbed following oral administration.

Distribution: Extensively distributed to extravascular tissues.

Protein Binding: ≥99%.

Metabolism/Excretion: Primarily metabolized in the liver via the CYP3A4 isoenzyme. Primarily excreted in feces (26% as unchanged drug) with 12% being excreted in urine.

Half-Life: 111 hr.

Time/Action Profile ⬆ ⬇

(plasma concentrations)

ROUTE	ONSET	PEAK	DURATION
PO	unknown	10 hr	24 hr

Contraind./Precautions ⬆ ⬇

Contraindicated in:

SBP >150 mmHg or DBP >100 mmHg;
History of symptomatic HF within preceding 6 mo;
Patients at risk of or with history of arterial thrombotic events, including MI, angina, or ischemic stroke within preceding 6 mo;
Significant bleeding within preceding 6 mo;
End-stage renal disease;
Severe hepatic impairment;
OB: Pregnancy;
Lactation: Lactation.

Use Cautiously in:

Hypertension (control before initiating therapy);
HF;
Patients at risk for or with history of venous thromboembolism;
Patients at risk for or with history of bleeding;
Surgery (interruption of therapy recommended);
Thyroid abnormalities;
Aspirin or tartrazine hypersensitivity;
Moderate hepatic impairment (↓ dose);
Rep: Women of reproductive potential and men with female partners of reproductive potential;
Pedi: Safety and effectiveness not established in children.

Adv. Reactions/Side Effects ⬆ ⬇

CV: hypertension, DEEP VEIN THROMBOSIS, HF, HYPERTENSIVE CRISES, MI

Derm: palmar-plantar erythrodysesthesia syndrome, rash, impaired wound healing

Endo: hyperglycemia, hypothyroidism, hyperthyroidism

F and E: hypercalcemia, hyperkalemia, hypomagnesemia, hyponatremia, hypophosphatemia

GI: ↑amylase, ↑lipase, ↑liver enzymes, diarrhea, hyperbilirubinemia, nausea, stomatitis, vomiting, GI fistula, GI PERFORATION, HEPATOBILIARY DISORDERS

GU: ↑serum creatinine, ↓fertility, acute kidney injury, proteinuria

Hemat: ↑activated partial thromboplastin time, ↑hemoglobin, anemia, bleeding, lymphopenia, thrombocytopenia

Metab: ↓appetite, ↓weight

MS: back pain, osteonecrosis

Neuro: fatigue, delirium, POSTERIOR REVERSIBLE ENCEPHALOPATHY SYNDROME (PRES), STROKE

Resp: cough, dysphonia, dyspnea, PULMONARY EMBOLISM, RESPIRATORY FAILURE

Interactions ⬆ ⬇

Drug-drug:

Strong CYP3A inducers, including rifampin, may ↓ levels and effectiveness; avoid concurrent use.

Route/Dosage ⬆ ⬇

PO (Adults ): 1.34 mg once daily on Days 1–21 of a 28-day cycle (i.e., 21 days of tivozanib therapy followed by 7 days off therapy); continue until disease progression or unacceptable toxicity.

Hepatic Impairment

PO (Adults ): Moderate hepatic impairment: 0.89 mg once daily on Days 1–21 of a 28-day cycle (i.e., 21 days of tivozanib therapy followed by 7 days off therapy); continue until disease progression or unacceptable toxicity.

Availability ⬆ ⬇

Capsules: 0.89 mg; 1.34 mg

Assessment ⬆ ⬇

Ensure BP is controlled before starting therapy. Monitor BP after 2 wk and at least monthly thereafter during therapy. Treat with antihypertensive therapy when hypertension occurs. If Grade 3 hypertension occurs, hold therapy for Grade 3 hypertension that persists despite optimal antihypertensive therapy. Resume at ↓ dose when hypertension is controlled at ≤Grade 2. If Grade 4 hypertension occurs, permanently discontinue tivozanib. If tivozanib is held, monitor patients receiving antihypertensive therapy for hypotension.
Monitor for signs and symptoms of HF (dyspnea, swelling of ankles) during therapy. If Grade 3 HF occurs, hold tivozanib until improves to ≤Grade 1. Resume at ↓ dose or discontinue depending on severity and persistence HF. If Grade 4 HF occurs, permanently discontinue tivozanib.
Monitor for signs and symptoms of cardiac ischemia or arterial thromboembolic events (new chest pain or pressure; numbness or weakness on one side of body; pain in arms, back, neck or jaw; trouble talking; shortness of breath; sudden severe headache; vision changes; swelling in arms or legs) during therapy. If symptoms occur, permanently discontinue tivozanib.
Monitor patients who are at risk for or who have a history of bleeding during therapy. If Grade 3 or 4 bleeding event occurs, permanently discontinue tivozanib.
Monitor for signs and symptoms of PRES (seizures, headaches, visual disturbances, confusion, altered mental function) during therapy. If PRES symptoms occur, permanently discontinue tivozanib.

Lab Test Considerations:

Verify negative pregnancy test before starting therapy.
- Monitor for proteinuria before starting and periodically during therapy. If ≥2 g proteinuria in 24 hr, hold tivozanib until ≤2 g of proteinuria per 24 hr. Resume at a ↓ dose. Permanently discontinue tivozanib if nephrotic syndrome occurs.
- Monitor thyroid function before starting and periodically during therapy. Treat hypothyroidism and hyperthyroidism to maintain euthyroid state before and during therapy.

Implementation ⬆ ⬇

Administer medications for diarrhea, nausea, or vomiting before interrupting or ↓ dose. If dose ↓ is necessary, ↓ dose to 0.89 mg once daily for 21 days followed by 7 days off therapy.
May impair wound healing. Hold tivozanib for >24 days before elective surgery. Do not administer for >2 wk following major surgery and until adequate wound healing.
PO: Administer daily without regard to food for 21 days followed by 7 days off therapy. DNC: Swallow capsule whole; do not open, crush, or chew. Follow with a glass of water.

Patient/Family Teaching ⬆ ⬇

Explain purpose and side effects of medication to patient. Advise patient to read Patient Information before starting therapy. Instruct patient to take as directed. If a dose is missed, omit and take next scheduled dose; do not double doses. Emphasize importance of regular lab tests to monitor for side effects.
Advise patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult with health care professional before taking other medications.
Advise patient to notify health care professional if signs and symptoms of hypertension or hypertensive crisis (confusion, headaches, dizziness, chest pain, shortness of breath), HF, heart attack or blood clots, bleeding problems (unusual bleeding from gums; red or black tarry stools; heavier than usual menstrual or vaginal bleeding; bruises that happen without a known cause or get larger; headaches; dizziness or weakness; severe or uncontrolled bleeding; coughing up blood or blood clots; pink or brown urine; vomiting blood or vomit looks like coffee grounds; unexpected pain, swelling, or joint pain), PRES (headaches, seizures, confusion, blindness or change in vision, difficulty thinking) occur.
Instruct patient to notify health care professional of medication regimen prior to treatment or surgery.
Rep: May cause fetal harm. Advise women of reproductive potential and men with female partners of reproductive potential to use effective contraception during therapy and for 1 mo after last dose. Advise patient to avoid breastfeeding during therapy and for 1 mo after last dose. Instruct patient to notify health care professional promptly if pregnancy is suspected. May impair female and male fertility.

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Pronunciation ⬇

Classifications ⬆ ⬇

Indications ⬆ ⬇

Action ⬆ ⬇

Pharmacokinetics ⬆ ⬇