Therapeutic Classification: anti-infectives
Pharmacologic Classification: cephalosporin derivatives
Absorption: IV administration results in complete bioavailability of parent drug.
Distribution: Well distributed to tissues.
Metabolism/Excretion: Ceftaroline fosamil is rapidly converted by plasma phosphatases to ceftaroline, the active metabolite; 88% excreted in urine, 6% in feces.
Half-Life: 2.6 hr (after multiple doses).
Acute Bacterial Skin/Skin Structure Infections
- IV (Adults ): 600 mg every 12 hr for 5–14 days.
- IV (Children 2–17 yr and >33 kg): 400 mg every 8 hr for 5–14 days or 600 mg every 12 hr for 5–14 days.
- IV (Children 2–17 yr and ≤33 kg): 12 mg/kg every 8 hr for 5–14 days.
- IV (Children 2 mo–<2 yr): 8 mg/kg every 8 hr for 5–14 days.
- IV (Neonates 0–<2 mo): 6 mg/kg every 8 hr for 5–14 days.
Renal Impairment
- IV (Adults ): CCr >30 to ≤50 mL/min: 400 mg every 12 hr; CCr ≥15 to ≤30 mL/min: 300 mg every 12 hr; CCr <15 mL/min including hemodialysis: 200 mg every 12 hr.
Community-Acquired Pneumonia
- IV (Adults ): 600 mg every 12 hr for 5–7 days.
- IV (Children 2–17 yr and >33 kg): 400 mg every 8 hr for 5–14 days or 600 mg every 12 hr for 5–14 days.
- IV (Children 2–17 yr and ≤33 kg): 12 mg/kg every 8 hr for 5–14 days.
- IV (Children 2 mo–<2 yr): 8 mg/kg every 8 hr for 5–14 days.
Renal Impairment
- IV (Adults ): CCr 31–50 mL/min: 400 mg every 12 hr; CCr 15–30 mL/min: 300 mg every 12 hr; CCr <15 mL/min including hemodialysis: 200 mg every 12 hr.
