Risk of irritation ↑ by other topical skin-care products (aftershave, cover-up, make-up, perfumes, colognes).
Route/Dosage⬆⬇
(Adults and Children ≥12 yr): Apply once daily at bedtime.
Availability⬆⬇
(Generic available)
Cream: 0.1%
Gel: 0.1%; 0.3% OTC
Lotion: 0.1%
Solution: 0.1%
In combination with:
benzoyl peroxide (Epiduo, Epiduo Forte); benzoyl peroxide and clindamycin (Cabtreo) (see Combination Drugs).
Assessment⬆⬇
Assess skin prior to and periodically during therapy. Transient worsening of acne may occur at initiation of therapy. Note degree of skin dryness, erythema, and itching. Usually occur during 1st 2–4 wk of therapy. May need to ↓ frequency or discontinue therapy.
Implementation⬆⬇
Topical Cleanse area with mild or soapless cleanser before applying medication. Apply thin film of cream to areas where acne lesions appear, once daily at nighttime. A mild transitory sensation of warmth or slight stinging may occur shortly after application. Avoid contact with the eyes, lips, angles of the nose, and mucous membranes. Do not apply to cuts, abrasions, eczematous or sunburned skin. May use moisturizers but avoid products containing alpha hydroxy or glycolic acid. Avoid waxing skin in treated area.
Patient/Family Teaching⬆⬇
Explain purpose and side effects of medication to patient. Advise patient to read Patient Information before starting therapy. Advise patient on correct technique for application of cream.
Advise patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult with health care professional before taking other medications.
Advise patient that a temporary worsening of acne may occur at beginning of therapy.
Advise patient to use sunscreen and protective clothing to prevent photosensitivity reactions. Health care professional should be consulted about sunscreen, as some sunscreens may worsen acne.
Rep: Advise women of reproductive potential to notify health care professional if pregnancy is planned or suspected or if breastfeeding.
Evaluation/Desired Outcomes⬆⬇
Reduction in inflammatory and noninflammatory acne lesions.
