Comparison of Thrombolytic Drugs

Comparison of Thrombolytic Drugs

	tPA	Streptokinase	APSAC
Half-life	6 min	20 min	100 min
Dosage	100 mg^a	1.5 million units	30 units
Administration	90 min	30-60 min	5 min
Fibrin selective	Yes	No	Partial
Artery patency rate^b	79%	40%	63%
ICH	0.6%	0.3%	0.6%
Lives saved/1000 treated	35	25	25
Antigenic	No	Yes	Yes
Hypotension	No	Yes	Yes
Heparin required	Yes	No	No
Cost per dose	$2750	$537	$2368

APSAC, anisoylated plasminogen streptokinase activator complex; ICH, intracranial hemorrhage; tPA, tissue plasminogen activator.

^a15 mg bolus, then 0.75 mg/kg over 30 minutes (maximum 50 mg), then 0.5 mg/kg over 60 minutes (maximum 35 mg) to provide total of 100 mg over 90 minutes.

^bArtery patency rate at 90 minutes after treatment.

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Table 15-3