Nociception refers to the normal functioning of physiologic systems that leads to the perception of noxious stimuli as being painful (Pasero & Portenoy, 2011). In short, it means “normal” pain transmission occurs when tissue damage (e.g., surgical incision) produces enough noxious stimuli to activate free nerve endings (nociceptors) and initiate the transmission of pain. Somatic (bone) and visceral (organ) pain are types of nociceptive pain. In contrast to nociceptive pain, neuropathic pain is sustained by the abnormal processing of stimuli from the peripheral or central nervous system or both (Pasero & Portenoy, 2011).