The skin represents the largest thermoregulatory organ in the body. Burn injury represents a disruption in the body’s ability to maintain a normal body temperature; therefore, avoidance of hypothermia is important. This can be accomplished by the use of convective heat warmers and fluid warmers. Significant blood loss can occur during the excision of burns; fluid resuscitation may have to be continued in the recovery phase. Inspection of the burn dressing should occur; the graft site should be protected from pressure and excessive movement, and bleeding through the dressings may indicate the need for better hemostasis, to be performed at bedside or with a return to the operating room. Burn patients also need to be monitored for oxygenation in light of significant resuscitation that may lead to pulmonary edema or exacerbation of pulmonary damage from the initial fire.