The term polypharmacy carries a negative connotation, in contrast to multimodal therapy or combination therapy. Whereas multimodal therapy is based on rational combinations of analgesics with differing underlying mechanisms to achieve the greatest benefit in pain control, polypharmacy suggests the use of drug combinations that are irrational and less effective or less safe than would be a regimen that had fewer or different agents (Pasero & Portenoy, 2011). For example, combining two NSAIDs in a treatment plan is not advised as this is unlikely to improve analgesia and would increase the patient’s risk of GI toxicity (Pasero, Portenoy, & McCaffery, 2011). Important principles of safe drug administration are to be aware of the potential for interactions specific to each analgesic and to avoid unnecessary duplicate prescribing that can lead to toxicities (Hanks, Roberts, & Davies, 2004).