Vulvectomy, which includes the en bloc removal of the vulva and surrounding tissues, poses particular postoperative challenges (Hoffman et al., 2012i). Vacuum-assisted closure therapy may be applied in the operating room while the patient remains anesthetized. The therapy continues for 8 to 10 days postoperatively, reducing wound healing to scarring time (Narducci et al., 2012). In patients where VAC therapy is not used, the vulvar wound is initially kept dry and clean except for perineal irrigation with normal saline, followed by air drying. Underwear should not be worn, and garments should be loose-fitting to avoid tension and pressure on the incision. The most common complication is separation of a portion of the incision. Debridement may be needed with healing by secondary intention or VAC therapy applied.