CSF IgG Index
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CSF IgG
CSF Albumin
Serum IgG
Serum Albumin
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CSF IgG Index

The IgG Index is uperior to the IgG to albumin ratio or measurement of IgG in CSF alone.   It may be used to:

  • To evaluate the integrity and permeability of the blood-CSF barrier
  • To measure the local synthesis of IgG within the CNS
  • Evaluation of several conditions (see below); but most notably:
    • IgG index is the first CSF abnormality in early MS with >0.7 in 86-94% cases
    • Elevated IgG and IgG index may be detected in neurosarcoidosis
  • A traumatic tap invalidates results