A. Common

1. Solid Tumor Neoplastic Diseases
   1. ~10% of tumors overall
   2. Pancreatic carcinomas: up to 50% have thromboembolic events
2. Smoking (tobacco)
3. Pregnancy
4. Diabetes mellitus
5. Oral contraceptives - particularly higher dose estrogen pills (especially in smokers)
6. Hyperlipidemias
7. Immobilization
   1. Hospital recovery
   2. Postoperative Course - especially with hip surgery
8. Disseminated Intravascular Coagulopathy (DIC): shock, sepsis, leukemia, pancreatitis

B. Less Common

1. Nephrotic syndrome: loss of important fibrinolytic components
2. Myeloproliferative disorders
3. Hyperviscosity Syndromes
   1. Sickle Cell Anemia
   2. Polycythemia
   3. Hypergammaglobulinemia
4. Vasculitis
   1. ANCA associated diseases
   2. Thromboangiitis obliterans (Buerger's Disease)
   3. Cryoglobulinemia
5. Systemic lupus erythematosus (SLE)
6. Anti-cardiolipin syndrome
7. Homocystinuria and Hyperhomocysteinemia
   1. Especially arterial thromboemboli with accelerated atherosclerosis
   2. Primary (genetic) and more common secondary forms
8. Microangiopathic Hemolytic Syndromes
   1. Thrombotic thrombocytopenic purpura (TTP)
   2. Hemolytic Uremic Syndrome (HUS)
9. Genetic Mutations
   1. Factor V Leiden
   2. Factor VII mutation
   3. Factor II mutation

C. Rare

1. Paroxysmal nocturnal hemoglobinuria (PNH)
2. Defects in anticoagulation proteins: low antithrombin III, protein C, or protein S
3. Cryofibrinogenemia
4. Cholesterol emboli
5. Coumadin necrosis