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A. Noninherited

  1. Stroke or transient ischemic attack (posterior circulation)
  2. Multiple Sclerosis
  3. Sarcoidosis
  4. Paraneoplastic Disorder [2]
    1. Breast Cancer
    2. Lung Cancers (mainly small cell)
    3. Ovarian Cancer
    4. Uterine or Cervical Cancer
  5. Alcoholic cerebellar degeneration
  6. Tumor or abscess of posterior fossa
    1. Primary brain tumor
    2. Metastatic tumor
    3. Primary CNS lymphoma
  7. Toxins
    1. Lead
    2. Anticonvulsants
    3. Salicylates
    4. Aminoglycosides
    5. Sedatives
    6. Fluorouracil
    7. Cytarabine
  8. Miller-Fisher Syndrome (variant of Guillain-Barre Syndrome)
  9. Infection
    1. Viral encephalitis
    2. HIV
    3. Creutzfeldt-Jacob Disease
  10. Thiamine or Vitamin E deficiency
  11. Autoimmune Associated
    1. Systemic lupus erythrmatosus (SLE)
    2. Sjogren's Syndrome
    3. Hashimoto's Thyroiditis
    4. Autoantibody Mediated Cerebellar Ataxia (Anti-GAD or anti-gliadin Abs)
  12. Spontaneous olivopontocerebellar atrophy

B. Inherited

  1. Friedreich's Ataxia
  2. Spinocerebellar Ataxia
    1. Type 1 (olivopontocerebellar atrophy)
    2. Type 2 (Wadia's ataxia)
    3. Type 3 (Machado-Joseph disease)
    4. Type 4 (with sensory loss)
  3. Dentatorubropallidoluysian atrophy
  4. Dominant periodic ataxia
  5. Ataxia-telangiectasia

References

  1. Alderson LM and Delalle I. 2002. NEJM. 346(13):1009 abstract
  2. Dalmau J, Gonzalez RG, Letwill MF. 2007. NEJM. 356(6):612 (Case Record) abstract