1. All of the following are major contraindications to thrombolytic agents EXCEPT [1]:

   A. Onset of symptoms >24 hours prior to presentation
   B. Uncontrolled hypertension
   C. Thromboembolic stroke >1 month prior to presentation
   D. Cerebral Metastases
   E. Prolonged cardiopulmonary resuscitation

2. Which of the following calcium channel blocking agents is preferred in patients with

A. Amlodipine
B. Isradipine
C. Verapamil
D. Diltiazem
E. Nifedipine

• All of the following are true concerning inotropic agents EXCEPT [3]:

  A. Currently available inotropic agents affect calcium levels in cardiac muscle
  B. Digoxin provides mild improvement in symptoms of systolic congestive heart failure
  C. Amrinone and milrinone cause vasodilation in addition to increasing inotropic activity
  D. Milrinone and dobutamine cause significant tachycardia and increase risk of arrhythmias
  E. High dose dopamine has alpha- and beta-adrenergic as well as dopaminergic activities

• All of the following are true concerning cephalosporins EXCEPT [4]:

A. Fourth generation cephalosporins have the broadest spectrum
B. None of the cephalosporins have significant activity against Enterococcus faecium
C. Xanthomonas and Citrobacter are best treated with combination antibiotics
D. Skin infections in immunocompetent hosts are reliably treated with first generationcephalosporins
E. Second generation cephalosporins have reliable activity against ß-lactamase positive bacteria

• All of the following are true concerning hydroxymethylglutyryl-coenzyme A (HMG-CoA)

A. They reduce LDL cholesterol ~10-40% and increase or maintain HDL cholesterol levels
B. They effectively reduce cholesterol in nearly all patients
C. Atorvastatin reduces VLDL cholesterol and triglycerides as well as LDL cholesterol
D. Specific HMG-CoA reductase inhibitors reduce primary and secondary cardiac events
E. Laboratory monitoring for liver damage with HMG-CoA reductase inhibitors should onlybe carried out in patients with pre-existing liver disease

All of the following are true concerning niacin therapy EXCEPT [6]:

A. Niacin has been shown to reduce cardiac events and slow the progression of atherosclerotic plaques
B. Niacin is the preferred agent for mixed lipid disorders in patients who cannot tolerateHMG CoA Reductase inhibitors
C. Slow release forms have significantly reduced rates of flushing and nausea
D. Niacin lowers VLDL, LDL and moderately increases in HDL
E. Niacin causes hepatitis and liver function tests must be monitored during use

Diuretic agents are primary agents for all of the following conditions EXCEPT [7]:

A. Cirrhosis with ascites
B. Congestive Heart Failure with Systolic Dysfunction
C. Congestive Heart Failure with Diastolic Dysfunction
D. Acute Pulmonary Edema from any cause
E. Hypertension

Which ONE of the following is TRUE concerning loop diuretics [8] ?

A. They increase the serum calcium level
B. They can precipitate severe arrhythmias by depleting potassium and magnesium
C. They inhibit the Na/K ATPase in the loop of Henle
D. After thiazide drugs, they are the most potent of the diuretic agents
E. They are the drugs of choice for the initial treatment of cirrhotic ascites

Dopamine actions through specific dopamine receptors play a role in all of the following

A. Renal afferent arteriolar vasodilation
B. Cardiac contractility
C. Nausea receptors in the brain
D. Movement control (Substantia Nigra)
E. Control of prolactin secretion (pituitary / hypothalamus)

• All of the following are Phase II Drug Metabolism Reactions EXCEPT [10]:

  A. Glutathione Conjugation
  B. Aminoacylation
  C. Acetylation
  D. Oxidation
  E. Glucuronidation

---

Answers

1. C
2. A
3. D
4. E
5. E
6. A
7. C
8. B
9. B
10. D