1. All of the following are true concerning colon cancer treatment EXCEPT [1]:

   A. Combination irinotecan (camptosar) + 5-fluorouracil + leucovorin is standard treatment for metastatic colon cancers (Dukes D, Stage IV)
   B. Addition of levamisole to 5-fluorouracil and leucovorin increases survival rates ~10%
   C. Adjuvant chemotherapy is standard of care for Dukes C colon cancer
   D. Adjuvant therapy is not standard for Dukes B1 colon cancer
   E. Survival with very early stage (Dukes A, Stage I) colon cancer is nearly normal

2. The most effective modality for the treatment of renal carcinoma is [2]:

   A. Immunotherapy with low dose interleukin 2 ± interferon alpha
   B. Cisplatin ± 5-fluorouracil
   C. Radiation therapy
   D. High dose interleukin 2
   E. Combined chemoradiotherapy

3. All of the following are TRUE concerning Hereditary Nonpolyposis Colon Cancer (Lynch Syndrome) EXCEPT [3]:

   A. Responsible for ~6% of all colon cancers
   B. Increased risk of endometrial cancer as well as colonic neoplasms
   C. Caused by mutations in genes which code for DNA mismatch repair proteins
   D. Mutations in these mismatch repair genes confer ~20% lifetime risk of colon cancer
   E. Inactivation these mismatch repair genes leads to "Microsatellite Instability" (MSI)

4. Concerning the treatment of osteosarcoma, which ONE of the following is TRUE [4] ?

   A. Survival is >80% with amputation of limb containing the tumor
   B. Five year survival with operable, non-metastatic osteosarcoma is <25%
   C. Adjuvant or neoadjuvant chemotherapy improves survival to 75-80% in nonmetastatic cases
   D. Multidrug regimens are significantly more effective than two drug combinations
   E. Expression of multidrug resistance gene mdr1 (P glycoprotein) does not affect outcome

5. All of the following concerning head and neck cancer are true EXCEPT [5]:

   A. Routine use of adjuvant chemotherapy should be discouraged at this time
   B. Patients with poor therapeutic responses usually die of complications of local disease
   C. Risk factors include tobacco, alcohol, and nickel refining
   D. Dietary carotenoids (high intake fruits and vegetables)
   E. Smoking during radiation therapy has no effect on response rates

6. Which ONE of the following concerning hepatocellular cancer is NOT correct [6] ?

   A. Chronic infection with hepatitis B and C viruses increases risk of hepatocellular cancer
   B. Coinfection with hepatitis B and C viruses increases risk of developing cancer above either virus alone
   C. Interferon alpha treatment of chronic viral hepatitis reduces risk of hepatocellular cancer
   D. Duration of cirrhosis is not a risk factor for the development of hepatocellular cancer
   E. Alcoholic cirrhosis is an additional risk factor for development of hepatocellular cancer

7. All of the following are complications of Chronic Lymphocytic Leukemia (CLL) EXCEPT [7]:

   A. Autoimmune Thrombocytopenia
   B. Hypogammaglobulinemia
   C. Increased risk of bacterial, fungal, and herpes zoster infection
   D. Increased secondary cancer rates (including lung and skin)
   E. Transformation to Hodgkin's Lymphoma

8. The most effective single agent for the treatmen of pancreatic cancer is [8]:

   A. Cisplatin
   B. Paclitaxel (Taxol®)
   C. Gemcitabine (Gemzar®)
   D. Cyclophosphamide (Cytoxan®)
   E. Herceptin® (anti-her2/neu monoclonal antibody, trastuzumab)

9. Concerning Non-Hodgkin's Lymphoma (NHL), select the correct answer [9]:

I. Most NHL in immunocompromised patients are positive for simian virus 40 (SV40) DNAII. The most accurate prognostic markers for NHL utilize the molecular (genomic) signatures of the tumor itself, rather than clinical variables or pure histopathologyIII. The majority are curable with high dose chemotherapy and stem cell rescueIV. The majority are derived from B lymphocytes rather than T lymphocytes
V. Epstein-Barr Viral DNA is virtually never found in NHL tissue
A. I, II, and III are correct
B. I and III are correct
C. II and IV are correct
D. IV is correct
E. V is correct

10. Which of the following statements concerning Acute Lymphocytic Leukemia (ALL) is FALSE [10] ?

    A. ALL is the most common form of leukemia in children
    B. Most ALL cases arise from cases of chronic lymphocytic leukemia
    C. Adult ALL accounts for ~30% of cases of ALL (~1000 new cases per year)
    D. ALL has a high propensity for central nervous system (CNS) involvement
    E. Most ALL are derived from blast phase B lymphocytes

11. Select the correct answer concerning Multiple Myeloma [11]:
I. Multiple myeloma cells arise from B lymphocyte-derived, antibody secreting plasma cellsII. Multiple myeloma is nearly 100% fatal, with median lifespan of 3-4 yearsIII. The proteasome inhibitor bortezomib (Velcade®, PS-341) has shown >30% response ratein patients with relapsed and refractory multiple myelomaIV. Thalidomide alone induces remissions in >50% of patients with relapsed multiple myeloma
V. High dose chemotherapy with stem cell rescue does not prolong median lifespan of patients <65 years of age with multiple myeloma
A. I, II and III are correct
B. I and III are correct
C. II and IV are correct
D. IV is correct
E. V is correct

Answers

1. B
2. A
3. D
4. C
5. E
6. D
7. E
8. C
9. C
10. B
11. A